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i'm having a hard time understanding how entwine and greyhound could be integrated

Yes, Entwine would add a dependency, which the project might not want. A simpler approach would be to start by implementing Greyhound access. There are two JavaScript APIs that already implement support for it, and ...

One possibility is to use Entwine https://entwine.io to organize the data. Entwine is multi-threaded and the storage backend is adaptable to whatever you might need. We have some massive Entwine-organized data collections http://speck.ly http://potree.entwine.io that are available online as web ...

> And also, with PDAL the actual file reading and writing doesn't happen during the for loops, which means that for example, when opening big files the UI will be unresponsive until PDAL is done reading

PDAL has a "streaming" API that will allow you to have libLAS' one-at-a-time reading behavior ...

It is possible to colorize point clouds using PDAL http://pdal.io See https://github.com/PDAL/PDAL/blob/maste ... lorize.xml for an example PDAL pipeline to take a LAS file plus a GDAL-readable raster file and produce colorized output.